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Fueling the Viral Fire With mRNA

2021 John A. Catanzaro, CEO of Neo7Logix

In the next few months to years, the existing trend of mRNA vaccines will reveal the shortfalls associated with their current designs. Currently, greater than 60% of the population affected by the COVID global outbreak are refusing the mRNA-based vaccines over concerns of safety and long-term adverse health effects.

RNA viruses are like parasites, and their replication requires host cell functions. mRNA degrades in an accelerated manner when introduced into the infected host cell. It is also subject to rapid decay and unpredictable by nature of its biogenesis. Therefore, mRNA is extremely difficult and unreliable for assuring vaccine protection with effective long-term immunity, if at all. mRNA-based vaccines currently used for the COVID-19 outbreak are worrisome. RNA viruses, particularly Coronavirus species, have the peculiar ability to proofread in the viral replication cycle. A correcting enzyme that diminishes the number of mutations can switch the proofreading mechanisms on or off depending on the context, allowing them to rapidly adapt to new environments without losing replicative fidelity. This proofreading ability can short circuit vaccine mRNA’s intended effect in stimulating a reliable immune response against the viral replicating machinery.

Additional concerns related to mRNA vaccine design are the random distribution of viral-like proteins. Antiviral defense strategies require direct target effects. Currently, there is no effective treatment against COVID-19 for this reason. Precision target versus random distribution designs would better influence the viral replication cycle and eradicate the virus with long-term efficacy. The prodigious diversity of viruses, their unprecedented rate of evolution, and the vast repertoire of their interactions with the host cell require a more deliberate design that considers the translation system.

Adverse downstream effects created by the random, unpredictable nature of the current mRNA vaccine include:

  1. No effective long term immunity

The best defense against the virus is a treatment that eradicates it for the long term. Immune treatment with multi-target with multi-mechanistic features mimicking the natural immune cascade of immunity is needed. This type of design can directly address the viral replication and infection rate and facilitate the recovery of infected people while also controlling the spread of the virus.

One should carefully consider all of the risks associated with the current mRNA vaccines available before deciding to vaccinate.

Written by

John A. Catanzaro is CEO of Neo7logix, a bioscience company that designs precision and personalized treatment designs. www.neo7logix.com

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